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Foam cells in 4 human atherosclerotic plaques reacted with 3 rat monoclonal antibodies directed against T.200 ('anti-leucocyte common' antibody), HLA-Class II molecules and macrophage cytoplasm, respectively. Smooth muscle cells did not react. The results support the view that foam cells are monocyte-derived macrophages.

Type

Journal article

Journal

Atherosclerosis

Publication Date

12/1984

Volume

53

Pages

265 - 271

Keywords

Adult, Animals, Antibodies, Monoclonal, Aorta, Arteriosclerosis, Coronary Vessels, Female, Foam Cells, Humans, Immunoenzyme Techniques, Macrophages, Male, Middle Aged, Monocytes, Rats