Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Trans-hydrogen-bond deuterium isotope effects of Watson-Crick A:U and A:T base pairs of 10 homologous RNA and DNA duplexes are compared. The isotope effect at 13C2 of adenosine residues due to deuterium/protium substitution at the imino H3 site, 2hDelta13C2, is larger in RNA than in DNA. The virtually consistent larger isotope effects in RNA suggest that the N1...N3 hydrogen bonds of A:U base pairs of RNA are stronger than those of the A:T base pairs of DNA.

Original publication

DOI

10.1021/ja048981t

Type

Journal article

Journal

J Am Chem Soc

Publication Date

12/05/2004

Volume

126

Pages

5688 - 5689

Keywords

Base Pairing, Base Sequence, DNA, Hydrogen Bonding, Magnetic Resonance Spectroscopy, Molecular Structure, RNA