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We sought to investigate the contribution of extended runs of homozygosity in a genome-wide association dataset of 1,955 Alzheimer's disease cases and 955 elderly screened controls genotyped for 529,205 autosomal single nucleotide polymorphisms. Tracts of homozygosity may mark regions inherited from a common ancestor and could reflect disease loci if observed more frequently in cases than controls. We found no excess of homozygous tracts in Alzheimer's disease cases compared to controls and no individual run of homozygosity showed association to Alzheimer's disease.

Original publication

DOI

10.1002/ajmg.b.31216

Type

Journal article

Journal

Am J Med Genet B Neuropsychiatr Genet

Publication Date

12/2011

Volume

156B

Pages

764 - 771

Keywords

Aged, Aged, 80 and over, Alzheimer Disease, Case-Control Studies, Chromosomes, Human, Pair 8, Female, Genes, Genetic Predisposition to Disease, Genome-Wide Association Study, Homozygote, Humans, Male