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We studied the effect of the α 2 ‐adrenoceptor agonist, clonidine, and bright artificial light ( > 2500 lux) on the nocturnal increase in plasma melatonin in normal subjects. Clonidine (1.5 μg/kg, intravenously) was without effect on plasma melatonin concentration. In contrast, bright light treatment abolished the increase in night‐time melatonin. Bright light is a simple and effective means of altering melatonin secretion in humans. Copyright © 1988 John Wiley & Sons, Ltd.

Original publication

DOI

10.1002/hup.470030107

Type

Journal article

Journal

Human Psychopharmacology: Clinical and Experimental

Publication Date

01/01/1988

Volume

3

Pages

43 - 46