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In treated hypertensive patients plasma melatonin levels were lower in subjects receiving beta-adrenoceptor blockers than those treated with diuretics. Melatonin concentrations in middle-aged and young control subjects were similar to each other and to those of the diuretic-treated patients. The results suggest that treatment with beta-adrenoceptor blockers causes a persistent reduction in plasma melatonin but it is unclear if this finding has clinical implications.


Journal article


Br J Clin Pharmacol

Publication Date





258 - 260


Adrenergic beta-Antagonists, Adult, Age Factors, Aged, Diuretics, Female, Humans, Hypertension, Male, Melatonin, Middle Aged