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Radioligand binding to intact platelets was carried out in antidepressant-free patients and the 1 mg dexamethasone suppression test (DST) was performed. There were no differences in binding characteristics between patients and controls for either [3H]yohimbine or [3H]imipramine. There were no differences in binding between patients classified as endogenous using the Newcastle Scale, compared with non-endogenous patients, and no difference between DST suppressors and non-suppressors. The severity of depression did not affect binding values. After 4-6 weeks antidepressant treatment [3H]yohimbine binding was significantly reduced but [3H]imipramine binding was unaffected.

Type

Journal article

Journal

Psychol Med

Publication Date

11/1986

Volume

16

Pages

765 - 773

Keywords

Adult, Aged, Amitriptyline, Blood Platelets, Depressive Disorder, Dexamethasone, Electroconvulsive Therapy, Female, Humans, Hydrocortisone, Imipramine, Male, Middle Aged, Psychological Tests, Receptors, Adrenergic, alpha, Receptors, Serotonin, Yohimbine