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Patients with Alzheimer disease (AD) had reduced regional cerebral blood flow (rCBF) in the posterior parietotemporal region compared with controls, as determined with technetium-99m hexamethyl propyleneamine oxime and single photon emission tomography. Central cholinergic stimulation with physostigmine produced a focal increase in rCBF in the posterior parietotemporal region in the patients with AD but not in controls.

Type

Journal article

Journal

Lancet

Publication Date

23/06/1990

Volume

335

Pages

1484 - 1487

Keywords

Aged, Alzheimer Disease, Analysis of Variance, Cerebrovascular Circulation, Drug Evaluation, Female, Glycopyrrolate, Humans, Infusions, Intravenous, Male, Middle Aged, Organotechnetium Compounds, Oximes, Parasympathetic Nervous System, Parietal Lobe, Physostigmine, Technetium Tc 99m Exametazime, Temporal Lobe, Tomography, Emission-Computed, Single-Photon