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L-Valine competes with tryptophan for transport into the brain and has previously been shown to decrease brain 5-HT synthesis. In the present study, the effect of L-valine on electrically evoked hippocampal 5-HT release was determined in the anaesthetized rat using microdialysis. In control animals two electrical stimulations of the dorsal raphe nucleus 120 min apart (S1 and S2, respectively) released similar amounts of 5-HT. In contrast, in animals which received L-valine (200 mg/kg) between stimulations, S2 released a significantly smaller amount of 5-HT than did S1, although basal 5-HT release was unchanged. The data demonstrate that L-valine decreases the electrically-evoked release of 5-HT in hippocampus in vivo.

Type

Journal article

Journal

Psychopharmacology (Berl)

Publication Date

1992

Volume

109

Pages

251 - 253

Keywords

Animals, Electric Stimulation, Hippocampus, Male, Microdialysis, Raphe Nuclei, Rats, Rats, Sprague-Dawley, Serotonin, Valine