Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Malaria infection reduces the binding capacity of benzodiazepine receptors in mice. We studied the efficacy of diazepam terminating seizures in children with falciparum malaria. Diazepam stopped seizures in fewer patients with malaria parasitaemia (chi(2)=3.93, P=0.047) and those with clinical diagnosis of malaria (chi(2)=9.84, P=0.002) compared to those without. However malaria was not identified as an independent risk factor for diazepam's failure to stop seizures in children.


Journal article


Epilepsy Res

Publication Date





215 - 218


Anticonvulsants, Child, Child, Preschool, Diazepam, Epilepsy, Female, Histidine, Humans, Infant, Injections, Intravenous, Malaria, Cerebral, Malaria, Falciparum, Male, Paraldehyde, Parasitemia, Receptors, GABA-A, Retrospective Studies, Risk Factors