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To determine how patterned visual activity regulates the development of axonal projections, we collected in vivo time-lapse images of retinal axons from albino Xenopus tadpoles in which binocular innervation of the optic tectum was induced. Axons added branch tips with nearly equal probability in all territories, but eliminated them preferentially from territory dominated by the opposite eye. This selective branch elimination was abolished by blockade of N-methyl-D-aspartate receptors. These results describe a correlation-based mechanism by which visual experience directly governs axon branch dynamics that contribute to the development of topographic maps.

Original publication

DOI

10.1126/science.1082545

Type

Journal article

Journal

Science

Publication Date

04/07/2003

Volume

301

Pages

66 - 70

Keywords

Animals, Axons, Brain Mapping, Computer Simulation, Cues, Dizocilpine Maleate, Dominance, Ocular, Evoked Potentials, Visual, Excitatory Amino Acid Antagonists, Image Processing, Computer-Assisted, Receptors, N-Methyl-D-Aspartate, Retina, Retinal Ganglion Cells, Superior Colliculi, Visual Pathways, Xenopus laevis