Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Thymocytes adoptively transferred into syngeneic irradiated recipients can be primed with antigen (KLH) to generate two types of helper function termed 'specific' and 'non-specific'. Low doses of KLH given without adjuvant generate high levels of non-specific compared to 'specific' helper T cells. Large doses of KLH given in adjuvant (FCA) generate high levels of both types of helper T cell. Explantations for this observation are discussed.

Type

Journal article

Journal

Immunology

Publication Date

11/1977

Volume

33

Pages

721 - 725

Keywords

Animals, Antibody Specificity, Antigen-Antibody Reactions, Antigens, B-Lymphocytes, Lymphocyte Cooperation, Mice, Mice, Inbred CBA, Radiation Effects, T-Lymphocytes, Transplantation, Isogeneic