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Five studies have been conducted with the atypical anti-psychotic amisulpride (100-1200 mg/day) involving 1358 patients with acute exacerbations of schizophrenia; four studies were short-term (4-8 weeks), double-blind studies and one was a 12-month, open, randomized comparison. Amisulpride improved positive symptoms consistently, and changes were more pronounced than with haloperidol, flupenthixol and risperidone; amisulpride showed a more rapid onset of action compared to haloperidol, and improvement in negative symptoms was more effective than with any comparator. An optimum response was obtained with amisulpride doses 400-800 mg/day. The long-term study confirmed the usefulness of amisulpride for maintenance treatment in schizophrenia, with a clear advantage over haloperidol, leading to better functioning and quality of life. Amisulpride caused fewer neurological side-effects than conventional anti-psychotics and less weight gain than risperidone, both of which are crucial factors for long-term compliance.

Original publication

DOI

10.1177/147323000102900601

Type

Journal article

Journal

J Int Med Res

Publication Date

11/2001

Volume

29

Pages

451 - 466

Keywords

Acute Disease, Adolescent, Adult, Aged, Antipsychotic Agents, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Male, Middle Aged, Schizophrenia, Sulpiride, Treatment Outcome