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New knowledge on how lymphocytes become tolerant to antigens is now enabling novel tolerance-harnessing strategies to enter the clinical arena. In the field of transplantation, monoclonal antibodies used either to deplete lymphocytes or to block T-cell function can induce tolerance in mice and non-human primates. Understanding the mechanisms underlying tolerance should enable application to the clinic. Harnessing of tolerance mechanisms may enable more judicious use of conventional immunosuppressive agents even to the point of maintenance monotherapy, so limiting drug side effects and ensuring compliance.

Type

Journal article

Journal

Curr Opin Chem Biol

Publication Date

08/2003

Volume

7

Pages

476 - 480

Keywords

Animals, Antibodies, Monoclonal, Clinical Trials as Topic, Drug Evaluation, Preclinical, Humans, Immunosuppression, Immunosuppressive Agents, Lymphocyte Depletion, Self Tolerance, T-Lymphocytes, Transplantation Immunology