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T cells require dual stimulation to become activated. When T cells encounter antigen-presenting cells, both the T cell receptor (TCR) and the CD28 coreceptor are ligated and activated. Michel and Acuto discuss how the adaptor SLP-76, which is recruited to the activated TCR complex, and the Rho family guanosine triphosphatase exchanger Vav-1, which is recruited by the CD28 receptor and TCR, may form a macromolecular complex that results in T cells activation. Vav-1 may serve as a central integrator between CD28 signaling and TCR signaling through its indirect effects on phosphoinositide 3-kinase-dependent signaling.

Original publication

DOI

10.1126/stke.2002.144.pe35

Type

Journal article

Journal

Sci STKE

Publication Date

06/08/2002

Volume

2002

Keywords

Adaptor Proteins, Signal Transducing, Animals, CD28 Antigens, Cell Cycle Proteins, Humans, Lymphocyte Activation, Phosphoproteins, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-vav, Receptors, Antigen, T-Cell, Signal Transduction