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Complement receptor 1-related protein Y (CrrY) is an important cell-surface regulator of complement that is unique to rodent species. The structure of rat CrrY domains 1-4 has been determined in two distinct crystal forms and reveals a 70° bend between domains 3 and 4. Comparisons of this structure with those of other complement regulators suggests that rearrangement of this interface may occur on forming the regulatory complex with C3b.

Original publication

DOI

10.1107/S1744309111016551

Type

Journal article

Journal

Acta Crystallogr Sect F Struct Biol Cryst Commun

Publication Date

01/07/2011

Volume

67

Pages

739 - 743

Keywords

Animals, Antigens, Surface, Crystallography, X-Ray, Humans, Models, Molecular, Protein Structure, Tertiary, Rats, Receptors, Cell Surface, Structural Homology, Protein