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Treatment with a non-depleting monoclonal antibody to CD4 in the presence of mouse thyroglobulin (MTg) inhibits the development of murine autoimmune thyroiditis. This unresponsiveness was transferrable since such treatment generated a population of donor cells which could suppress the thyroiditis induced in lightly irradiated recipients by subsequent challenge with specific antigen. The suppression appears to be both antigen specific and antigen dependent and seems to discriminate between TH1 and TH2 helper subsets in that there is no significant effect on anti-MTg autoantibodies after challenge.

Original publication

DOI

10.1002/eji.1830230431

Type

Journal article

Journal

Eur J Immunol

Publication Date

04/1993

Volume

23

Pages

965 - 968

Keywords

Animals, Antibody Formation, Antigen-Antibody Reactions, Antigens, CD4, CD4-Positive T-Lymphocytes, Female, Immune Tolerance, Immunity, Cellular, Immunization, Passive, Male, Mice, Mice, Inbred CBA, T-Lymphocytes, Regulatory, Thyroglobulin, Thyroiditis, Autoimmune