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Empirical studies attempting to explain tolerance to transplanted tissues have demonstrated a regulatory role for CD4+ T-cells. We here propose that regulatory T-cells mediating transplantion tolerance comprise two sets which can functionally complement each other. The CD4+CD25+ "natural regulator" arises in the thymus, and is preoccupied with self-antigens expressed at sites of inflammation. The second, comprising both CD4+CD25+ (FoxP3+) and CD4+CD25- Tr1-like cells are induced by persistent danger-free antigen in the periphery. The role of these cells is to moderate immune responses to prevent tissue destruction while allowing microbial elimination.

Original publication

DOI

10.1016/j.smim.2003.12.007

Type

Journal article

Journal

Semin Immunol

Publication Date

04/2004

Volume

16

Pages

119 - 126

Keywords

Animals, Antigens, CD, CD4-Positive T-Lymphocytes, DNA-Binding Proteins, Forkhead Transcription Factors, Humans, Immune Tolerance, Models, Immunological, Organ Transplantation, Receptors, Interleukin-2, Self Tolerance, T-Cell Antigen Receptor Specificity, T-Lymphocyte Subsets, T-Lymphocytes, Thymus Gland, Transplantation Immunology