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Dendritic cells (DCs) play an important role in initiating and directing T-cells towards immunity or tolerance. An important aim of emerging immunosuppressive strategies is to ensure that antigen is perceived in a 'tolerogenic context'. This would have obvious benefit in minimising the need for long-term drug maintenance in organ transplantation, hypersensitivity and autoimmune diseases. Here we review the biology of the interplay between the DC and T-cell, with a specific focus on therapeutic drugs targeting molecules that effect their interaction and function.

Type

Journal article

Journal

Curr Drug Targets Immune Endocr Metabol Disord

Publication Date

12/2005

Volume

5

Pages

397 - 411

Keywords

Animals, Antibodies, Monoclonal, Dendritic Cells, Graft Rejection, Humans, Immune Tolerance, Immunosuppression, Immunosuppressive Agents, T-Lymphocytes