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The regulatory mechanism which ensures that eukaryotic chromosomes replicate precisely once per cell cycle is a basic and essential cellular property of eukaryotes. This fundamental aspect of DNA replication is still poorly understood, but recent advances encourage the view that we may soon have a clearer picture of how this regulation is achieved. This review will discuss in particular the role of proteins in the minichromosome maintenance (MCM) family, which may hold the key to understanding how DNA is replicated once, and only once, per cell cycle.

Original publication

DOI

10.1002/bies.950180305

Type

Journal article

Journal

Bioessays

Publication Date

03/1996

Volume

18

Pages

183 - 190

Keywords

Animals, Cell Cycle Proteins, Chromosomes, DNA Replication, Nuclear Proteins, Xenopus