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The delineation of the beta-globin locus control region has led to a new understanding of the developmental regulation of the beta-globin gene cluster. It now seems that globin gene switching is effected through the sequential and mutually exclusive interaction of the locus control region with the embryonic, fetal and adult stage specific globin genes.

Type

Journal article

Journal

Curr Opin Biotechnol

Publication Date

12/1991

Volume

2

Pages

787 - 795

Keywords

Animals, Genes, Switch, Globins, Humans, Mice, Mice, Transgenic