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The principal mechanism underlying the reduced rate of protein synthesis in atrophied skeletal muscle is largely unknown. Eukaryotic elongation factor 2 kinase (eEF2k) impairs the ability of eukaryotic translation elongation factor 2 (eEF2) to bind to the ribosome via T56 phosphorylation. Perturbations in the eEF2k/eEF2 pathway during various stages of disuse muscle atrophy have been investigated utilizing a rat hind limb suspension (HS) model. Two distinct components of eEF2k/eEF2 pathway misregulation were demonstrated, observing a significant (P 

Original publication




Journal article


Am J Pathol

Publication Date





813 - 828


Rats, Animals, Elongation Factor 2 Kinase, Peptide Elongation Factor 2, Phosphorylation, Muscle, Skeletal, Muscular Atrophy, Ribosomal Protein S6 Kinases