What repeat expansion disorders can teach us about the Central Dogma.

Wang ET., Freudenreich CH., Gromak N., Jain A., Todd PK., Nagai Y.

Pathogenic repeat sequences underlie several human disorders, including amyotrophic lateral sclerosis, Huntington's disease, and myotonic dystrophy. Here, we speak to several researchers about how repeat sequences have been implicated in affecting all aspects of the Central Dogma of molecular biology through their effects on DNA, RNA, and protein.

DOI

10.1016/j.molcel.2022.12.017

Type

Journal article

Journal

Mol Cell

Publication Date

02/02/2023

Volume

83

Pages

324 - 329

Keywords

Humans, Amyotrophic Lateral Sclerosis, Proteins, Huntington Disease, RNA, Myotonic Dystrophy, Trinucleotide Repeat Expansion

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