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Several polymorphisms in the Disrupted-in-Schizophrenia-1 (DISC1) gene are reported to be associated with schizophrenia. However, to date, there has been little effort to evaluate the evidence for association systematically. We carried out an imputation-driven meta-analysis, the most comprehensive to date, using data collected from 10 candidate gene studies and three genome-wide association studies containing a total of 11 626 cases and 15 237 controls. We tested 1241 single-nucleotide polymorphisms in total, and estimated that our power to detect an effect from a variant with minor allele frequency >5% was 99% for an odds ratio of 1.5 and 51% for an odds ratio of 1.1. We find no evidence that common variants at the DISC1 locus are associated with schizophrenia.

Original publication

DOI

10.1038/mp.2011.41

Type

Journal article

Journal

Mol Psychiatry

Publication Date

06/2012

Volume

17

Pages

634 - 641

Keywords

European Continental Ancestry Group, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Nerve Tissue Proteins, Odds Ratio, Polymorphism, Single Nucleotide, Schizophrenia