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Determining the evolutionary relationships between genes is fundamental to comparative biological research. Here, we present SHOOT. SHOOT searches a user query sequence against a database of phylogenetic trees and returns a tree with the query sequence correctly placed within it. We show that SHOOT performs this analysis with comparable speed to a BLAST search. We demonstrate that SHOOT phylogenetic placements are as accurate as conventional tree inference, and it can identify orthologs with high accuracy. In summary, SHOOT is a fast and accurate tool for phylogenetic analyses of novel query sequences. It is available online at www.shoot.bio .

Original publication

DOI

10.1186/s13059-022-02652-8

Type

Journal article

Journal

Genome Biol

Publication Date

28/03/2022

Volume

23

Keywords

Orthology inference, Phylogenetic tree inference, Sequence similarity search