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The therapeutic effects of intravenous immunoglobulin (IVIG) on the stiff-person syndrome (SPS) have been described exclusively in case reports or open-label studies in terms of clinical outcomes. We investigate whether IVIG improves quality of life (QoL) in the SPS. Six patients with the classic form of SPS completed a generic QoL instrument, the SF-36, and a Visual Analogue Scale (VAS) before treatment as well as 2 weeks after completion of a course of IVIG. There was significant improvement in the SF-36 subscores for pain, social functioning, general mental health, and energy-vitality with treatment. The VAS also improved significantly. We conclude that treatment with IVIG improves QoL in the SPS.

Original publication




Journal article


Mov Disord

Publication Date





590 - 593


Aged, Female, Humans, Immunoglobulins, Intravenous, Male, Middle Aged, Quality of Life, Stiff-Person Syndrome, Surveys and Questionnaires, Time Factors, Treatment Outcome