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The scanning proton microprobe (SPM) is a powerful multi-elemental analytical instrument capable of elemental mapping at the parts per million level of sensitivity. In this report we demonstrate that the SPM is sufficiently sensitive and versatile to distinguish different regions of the human central nervous system on the basis of differences in their normal endogenous elemental composition.


Journal article


J Neurosci Methods

Publication Date





25 - 28


Brain Mapping, Cerebellum, Humans, Nervous System, Phosphorus, Protons, Spectrometry, X-Ray Emission, Sulfur