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Chronic pain is more common in women, however, our understanding of sex-specific differences in pain mechanisms is rudimentary. In this issue of Neuron, Luo et al., (2021) delineate a novel sex-specific neuro-immune pathway contributing to enhanced mechanical pain in females.

Original publication

DOI

10.1016/j.neuron.2021.08.006

Type

Journal article

Journal

Neuron

Publication Date

01/09/2021

Volume

109

Pages

2641 - 2642

Keywords

IL-17A, IL-23, TRPV1, mechanical pain, neuroimmune, pain, sex differences, Chronic Pain, Female, Humans, Male, Neurons, Sex Characteristics