Accumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs arise from the twinned processing of R-loops and topoisomerase I and may underlie neurological disorders and cancers.
Mol Cell Oncol
Cancer, DNA double-strand break, DNA repair, Neurodegenerative disease, R-loop, RNA/DNA hybrid, Senataxin, TDP1, Topoisomerase I, Transcription, XPF