The Spineless Origins of Prefrontal Cortex Dysfunction and Psychiatric Disorders.
Butt SJB., Lak A.
Fundamental research into early circuits of the neocortex provides insight into the etiology of mental illness. In this issue of Neuron, Chini et al. (2020) probe the consequences of combined genetic and environmental perturbation on emergent network activity in the prefrontal cortex, identifying a window for possible intervention.