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The chemokine eotaxin/CCL11 is an important mediator of leukocyte migration, but its effect on inflammatory cytokine signaling has not been explored. In this study, we find that CCL11 induces suppressor of cytokine signaling (SOCS)1 and SOCS3 expression in murine macrophages, human monocytes, and dendritic cells (DCs). We also discover that CCL11 inhibits GM-CSF-mediated STAT5 activation and IL-4-induced STAT6 activation in a range of hematopoietic cells. This blockade of cytokine signaling by CCL11 results in reduced differentiation and endocytic ability of DCs, implicating CCL11-induced SOCS as mediators of chemotactic inflammatory control. These findings demonstrate cross-talk between chemokine and cytokine responses, suggesting that myeloid cells tracking to the inflammatory site do not differentiate in the presence of this chemokine, revealing another role for SOCS in inflammatory regulation.

Original publication

DOI

10.1189/jlb.0708394

Type

Journal article

Journal

J Leukoc Biol

Publication Date

02/2009

Volume

85

Pages

289 - 297

Keywords

Animals, Cell Differentiation, Cell Line, Chemokine CCL11, Cytokines, Dendritic Cells, Endocytosis, GTP-Binding Protein alpha Subunits, Gi-Go, Granulocyte-Macrophage Colony-Stimulating Factor, Hematopoietic System, Humans, Inflammation Mediators, Interleukin-4, Macrophages, Mice, Mice, Inbred C57BL, Receptors, G-Protein-Coupled, Signal Transduction, Suppressor of Cytokine Signaling 1 Protein, Suppressor of Cytokine Signaling 3 Protein, Suppressor of Cytokine Signaling Proteins