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OBJECTIVE: To determine clinical predictors of lithium response in bipolar disorder. METHODS: Systematic review of studies examining clinical predictors of lithium response was conducted. Meta-analyses were performed when ≥2 studies examined the same potential predictor. RESULTS: A total of 71 studies, including over 12 000 patients, identified six predictors of good response: mania-depression-interval sequence [odds ratio (OR): 4.27; 95% CI: 2.61, 6.97; P 

Original publication




Journal article


Acta Psychiatr Scand

Publication Date





94 - 115


bipolar disorder, clinical aspects, lithium, Antimanic Agents, Bipolar Disorder, Body Mass Index, Female, Hospitalization, Humans, Lithium, Lithium Compounds, Male, Observational Studies as Topic, Predictive Value of Tests, Randomized Controlled Trials as Topic, Treatment Outcome