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Histone lysine methylation regulates a variety of nuclear processes including transcription and maintenance of genome integrity. Many attributes of the histone lysine methylation system suggest that it might also contribute to epigenetic memory. Here, we examine the recent advances in our understanding of three intensely-studied histone lysine methylation marks, focusing on the potential mechanisms by which these marks may be maintained during cell proliferation and adhere to the principles of epigenetics.

Original publication

DOI

10.2217/epi.09.42

Type

Journal article

Journal

Epigenomics

Publication Date

02/2010

Volume

2

Pages

151 - 161

Keywords

DNA (Cytosine-5-)-Methyltransferase, DNA Methylation, DNA Replication, Epigenesis, Genetic, Histones, Lysine, Models, Biological, Nucleosomes