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The coordination of growth, DNA replication and division in proliferating cells can be adequately explained by a 'clock + checkpoint' model. The clock is an underlying cyclical sequence of states; the checkpoints ensure that the cycle proceeds without mistakes. From the molecular complexities of the control system in modern eukaryotes, we isolate a simple network of positive and negative feedbacks that embodies a 'clock + checkpoints'. The model accounts for the fundamental physiological properties of mitotic cell divisions, evokes a new view of the meiotic program, and suggests how the control system may have evolved in the first place.

Original publication

DOI

10.1016/j.cub.2008.07.001

Type

Journal article

Journal

Curr Biol

Publication Date

09/09/2008

Volume

18

Pages

R759 - R768

Keywords

Cell Cycle, Cyclin-Dependent Kinases, Eukaryotic Cells, Models, Biological