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Increased understanding of the role of protein- and lipid-linked carbohydrates in a wide range of biological processes has led to interest in drugs that target the enzymes involved in glycosylation. But given the importance of carbohydrates in fundamental cellular processes such as protein folding, therapeutic strategies that modulate, rather than ablate, the activity of enzymes involved in glycosylation are likely to be a necessity. Two such approaches that use imino sugars to affect glycosylation enzymes now show considerable promise in the treatment of viral infections, such as hepatitis B, and glucosphingolipid storage disorders, such as Gaucher disease.

Original publication

DOI

10.1038/nrd708

Type

Journal article

Journal

Nat Rev Drug Discov

Publication Date

01/2002

Volume

1

Pages

65 - 75

Keywords

Animals, Antiviral Agents, Diarrhea Viruses, Bovine Viral, Disease Models, Animal, Gaucher Disease, Glycoproteins, Glycosphingolipids, Glycosylation, HIV, Hepatitis B virus, Humans, Mice, Protein Folding