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There is a necessity to better characterize uveal melanoma (UM) tumors according to their metastasis potential at an early stage. In this study we report the identification of potential biomarkers by a combination of proteomics-related approaches: the characterization of UM cell secretomes, the analysis of UM autoantibodies, and the differential depleted serum proteome analysis. We describe a possible role of cathepsin D, syntenin, and gp100 in UM as potential biomarkers.

Original publication

DOI

10.1021/pr070021t

Type

Journal article

Journal

J Proteome Res

Publication Date

07/2007

Volume

6

Pages

2802 - 2811

Keywords

Antibodies, Neoplasm, Autoantibodies, Biomarkers, Tumor, Cathepsin D, Cell Line, Tumor, Humans, Melanoma, Membrane Glycoproteins, Proteome, Uveal Neoplasms, gp100 Melanoma Antigen