Biomarker discovery from uveal melanoma secretomes: identification of gp100 and cathepsin D in patient serum.
Pardo M., García A., Antrobus R., Blanco MJ., Dwek RA., Zitzmann N.
There is a necessity to better characterize uveal melanoma (UM) tumors according to their metastasis potential at an early stage. In this study we report the identification of potential biomarkers by a combination of proteomics-related approaches: the characterization of UM cell secretomes, the analysis of UM autoantibodies, and the differential depleted serum proteome analysis. We describe a possible role of cathepsin D, syntenin, and gp100 in UM as potential biomarkers.