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The re-emergence of dengue virus as a significant human pathogen has lead to an increasing need for effective antivirals. Development of therapeutic agents with the ability to attenuate both the duration and severity of disease in patients after infection is particularly desirable in dengue endemic resource-poor settings. The reliance of dengue virus on endogenous processes during the late stages of infection prompts the development of molecules to interfere with and exploit these dependencies as potential antiviral therapies. Here we focus on the importance of N-linked glycan processing in infectious virion morphogenesis.

Original publication

DOI

10.1016/j.tim.2010.04.003

Type

Journal article

Journal

Trends Microbiol

Publication Date

07/2010

Volume

18

Pages

323 - 330

Keywords

Animals, Antiviral Agents, Cell Line, Cricetinae, Dengue, Dengue Virus, Enzyme Inhibitors, Glycosylation, Host-Pathogen Interactions, Humans, Inhibitory Concentration 50, Models, Biological, Protein Processing, Post-Translational, Viral Proteins