Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The intracellular localization of mRNA is an important mechanism for targeting proteins to their sites of function. Localized transcripts play key roles ranging from body axis determination to synapse plasticity, and recent studies highlight how common localized transcripts are in a variety of model organisms. In this review, we consider the full range of known mechanisms for delivering transcripts and anchoring them at their site of function. Finally, we evaluate the progress that has been made in the nervous system in understanding the mechanism and function of mRNA localization and translation regulation.

Original publication

DOI

10.1016/j.ceb.2009.11.011

Type

Journal article

Journal

Curr Opin Cell Biol

Publication Date

02/2010

Volume

22

Pages

112 - 119

Keywords

Animals, Biological Transport, Gene Expression Regulation, Developmental, Protein Biosynthesis, RNA, Messenger, Signal Transduction