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Only one broadly neutralizing anti-HIV antibody, 2G12, recognises the envelope sugars of HIV. In the present study, we show that 2G12 also recognises Candida albicans and Candida tropicalis with high affinity (11 nmol/l) through a carbohydrate-dependent interaction (50% inhibitory concentration for D-fructose, 12 mmol/l). This is the first report of a neutralizing HIV antibody displaying cross-reactivity with another pathogen, revealing that the carbohydrate neutralization determinant of HIV, defined by 2G12, is more widespread amongst immunogenic, microbial surfaces than previously recognized.

Original publication

DOI

10.1097/QAD.0b013e328314b5df

Type

Journal article

Journal

AIDS

Publication Date

18/10/2008

Volume

22

Pages

2214 - 2217

Keywords

Antibodies, Monoclonal, Antigens, Fungal, Candida, Cross Reactions, HIV Envelope Protein gp120, Humans, Molecular Mimicry