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We show that hepatitis C virus (HCV) p7 protein forms ion channels in black lipid membranes. HCV p7 ion channels are inhibited by long-alkyl-chain iminosugar derivatives, which have antiviral activity against the HCV surrogate bovine viral diarrhea virus. HCV p7 presents a potential target for antiviral therapy.

Original publication

DOI

10.1073/pnas.1031527100

Type

Journal article

Journal

Proc Natl Acad Sci U S A

Publication Date

13/05/2003

Volume

100

Pages

6104 - 6108

Keywords

Amino Acid Sequence, Carbohydrates, Hepacivirus, Imines, Ion Channels, Lipid Bilayers, Membrane Potentials, Molecular Sequence Data, Peptides, Viral Proteins