Discovery of the First Selective, Nonpeptidic Orexin 2 Receptor Agonists.
Heifetz A., Bodkin MJ., Biggin PC.
In this issue, Nagase and colleagues report the discovery of the first selective nonpeptidic orexin 2 receptor (OX2R) agonists. The discovery of these OX2R selective agonists opens up new avenues for therapies related to the activation of the orexin system, especially with respect to the treatment of sleep disorders such as narcolepsy.