Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

A complementary DNA probe corresponding to the beta-chain gene of Ti, the human T lymphocyte receptor, has been molecularly cloned. The chromosomal origin of the Ti beta gene was determined with the complementary DNA by screening a series of 12 cell hybrid (mouse X human) DNA's containing overlapping subsets of human chromosomes. DNA hybridization (Southern) experiments showed that the human Ti beta gene resides on chromosome 7 and is thus not linked to the immunoglobulin loci or to the major histocompatibility locus in humans.

Type

Journal article

Journal

Science

Publication Date

19/10/1984

Volume

226

Pages

348 - 349

Keywords

Animals, Chromosome Mapping, Chromosomes, Human, 6-12 and X, Cloning, Molecular, DNA, Genes, Genetic Linkage, Humans, Hybrid Cells, Immunoglobulin kappa-Chains, Major Histocompatibility Complex, Mice, Nucleic Acid Hybridization, Receptors, Antigen, T-Cell