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Using in vitro immunization, we have reconstructed three consecutive steps of an idiotype network to show that the nucleocapsid of Semliki Forest virus contains a specific 'receptor' for the cytoplasmic tail of the E2 spike glycoprotein. This interaction could be the basis for the highly selective inclusion of viral glycoproteins--and exclusion of host cell surface proteins--during virus budding.

Original publication

DOI

10.1038/336036a0

Type

Journal article

Journal

Nature

Publication Date

03/11/1988

Volume

336

Pages

36 - 42

Keywords

Antibodies, Monoclonal, Capsid, Epitopes, Immunoglobulin Idiotypes, Semliki forest virus, Viral Proteins