Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

E.coli is a simple organism with a complex, dual-membrane cell envelope. Moreover the two membranes differ in their compositions and thus also their permeabilities. Both membranes contain multiple proteins that perform a variety of functions. While it is clear that the membrane is not simply and inert environment that simply serves to contain the proteins, the precise details of its role and the complex interplay between membrane and proteins are far from understood. Here we employ atomistic and coarse-grain simulations to focus on the interaction of melittin with model inner and outer membranes and aggregation and diffusion of proteins in the outer membrane. The complexity of the membrane composition in terms of lipids and proteins is addressed. © 2013 IFMBE.

Original publication

DOI

10.1007/978-3-642-32183-2_91

Type

Conference paper

Publication Date

01/01/2013

Volume

40 IFMBE

Pages

376 - 379