Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

OBJECTIVES: Recent studies suggest that oscillatory beta activity could be used as a state biomarker in patients with Parkinson's disease for subthalamic closed-loop stimulation with the intention of improving clinical benefit. Here we investigate the feasibility of subthalamic recordings via a novel chronically implanted pulse generator. METHODS: Subthalamic local field potential recordings were obtained from eight patients before and during deep brain stimulation (DBS). All data were analyzed in the frequency domain using Fourier transform-based methods and compared between ON and OFF stimulation conditions. RESULTS: Distinct peaks of oscillatory beta band activity were found in 12 of 15 electrodes. DBS induced a significant frequency specific suppression of oscillatory beta activity (p = 0.002). CONCLUSION: The results of the study suggest that oscillatory beta band synchronization and its modulation by DBS is recordable with a system suitable for chronic implantation and may serve as a biomarker for subthalamic closed-loop stimulation in patients with Parkinson's disease.

Original publication

DOI

10.1111/ner.12348

Type

Journal article

Journal

Neuromodulation

Publication Date

01/2016

Volume

19

Pages

20 - 24

Keywords

Basal ganglia, beta oscillations, deep brain stimulation, local field potentials, subthalamic nucleus, Aged, Biophysics, Deep Brain Stimulation, Electrodes, Implanted, Evoked Potentials, Female, Humans, Male, Middle Aged, Parkinson Disease, Spectrum Analysis, Subthalamic Nucleus