Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Water-mediated bond formation: The structure of the peptide GPG-NH2 has been investigated in aqueous solution to understand the role of water in the formation of a β-turn. Using a combination of neutron diffraction enhanced by isotopic substitution, NMR spectroscopy, and computer simulations, it was found that water is an essential component to initiate folding in solution.

Original publication

DOI

10.1002/anie.201307657

Type

Journal article

Journal

Angew Chem Int Ed Engl

Publication Date

02/12/2013

Volume

52

Pages

13091 - 13095

Keywords

hydrogen bonds, peptides, structure elucidation, water, β-turns, Hydrogen Bonding, Models, Molecular, Peptides, Protein Folding, Protein Structure, Secondary, Water