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Several studies suggested that part of the genetic susceptibility for Type 1 diabetes (T1DM) is encoded by some polymorphisms of CTLA-4 gene (2q33) and of Vitamin D Receptor gene (VDR; 12q12-14). Our aim was to assess their contribution to T1DM genetic susceptibility in the Romanian population. We typed CTLA-4 49 A/G and VDR FokI (F/f), ApaI (A/a) and TaqI (T/t) polymorphisms by Sequence Specific Primer PCR (SSP-PCR) in 204 Romanian diabetic families (756 individuals: 212 T1DM probands and 544 unaffected parents and siblings). We studied alleles transmission using the Transmission Disequilibrium Test (TDT). We found an increased transmission of CTLA-4 49G allele to diabetics (54.8%, p=0.11). The transmission of F (56.1%, p=0.063), a (55.7%, p=0.061) and T (51.8%, p=0.37) alleles of VDR gene to diabetics was increased but did not reach statistical significance. In conclusion we found the same increased transmission of CTLA-4 49 G allele to diabetics as previously reported. VDR FoqI F allele seems to be predisposing while TaqI T allele seems to be protective.

Original publication

DOI

10.1111/j.1582-4934.2002.tb00312.x

Type

Journal article

Journal

J Cell Mol Med

Publication Date

01/2002

Volume

6

Pages

75 - 81

Keywords

Abatacept, Adolescent, Adult, Alleles, Antigens, CD, Antigens, Differentiation, CTLA-4 Antigen, Child, Child, Preschool, Diabetes Mellitus, Type 1, Female, Humans, Immunoconjugates, Immunoglobulin Fc Fragments, Infant, Male, Polymorphism, Genetic, Receptors, Calcitriol, Romania