Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Numerous pathogenic bacteria contain luxS, which is required for autoinducer-2 production. Here, we demonstrate that Neisseria meningitidis contains a functional copy of luxS that is necessary for full meningococcal virulence; strains with a luxS deletion are defective for bacteremia, a prerequisite of meningococcal pathogenesis.

Type

Journal article

Journal

Infect Immun

Publication Date

04/2002

Volume

70

Pages

2245 - 2248

Keywords

Animals, Bacteremia, Bacterial Proteins, Carbon-Sulfur Lyases, Homoserine, Lactones, Neisseria meningitidis, Rats, Rats, Wistar, Virulence