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Trans-hydrogen-bond deuterium isotope effects of Watson-Crick A:U and A:T base pairs of 10 homologous RNA and DNA duplexes are compared. The isotope effect at 13C2 of adenosine residues due to deuterium/protium substitution at the imino H3 site, 2hDelta13C2, is larger in RNA than in DNA. The virtually consistent larger isotope effects in RNA suggest that the N1...N3 hydrogen bonds of A:U base pairs of RNA are stronger than those of the A:T base pairs of DNA.

Original publication

DOI

10.1021/ja048981t

Type

Journal article

Journal

J Am Chem Soc

Publication Date

12/05/2004

Volume

126

Pages

5688 - 5689

Keywords

Base Pairing, Base Sequence, DNA, Hydrogen Bonding, Magnetic Resonance Spectroscopy, Molecular Structure, RNA