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Herein, we report the radiosynthesis of 18F-difluoromethylarenes via the assembly of three components, a boron reagent, ethyl bromofluoroacetate, and cyclotron-produced non-carrier added [18F]fluoride. The two key steps are a copper-catalysed cross-coupling reaction, and a Mn-mediated 18F-fluorodecarboxylation.

Original publication

DOI

10.1039/c8sc05096a

Type

Journal article

Journal

Chem Sci

Publication Date

21/03/2019

Volume

10

Pages

3237 - 3241