Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Opioids play an important role for the management of acute pain and in palliative care. The role of long-term opioid therapy in chronic non-malignant pain remains unclear and is the focus of much clinical research. There are concerns regarding analgesic tolerance, paradoxical pain and issues with dependence that can occur with chronic opioid use in the susceptible patient. In this review, we discuss how far human neuroimaging research has come in providing a mechanistic understanding of pain relief provided by opioids, and suggest avenues for further studies that are relevant to the management of chronic pain with opioids. This article is part of the Special Issue Section entitled 'Neuroimaging in Neuropharmacology'.

Original publication

DOI

10.1016/j.neuropharm.2013.06.035

Type

Journal article

Journal

Neuropharmacology

Publication Date

09/2014

Volume

84

Pages

123 - 130

Keywords

Analgesia, Neuroimaging, Opioids, Pain, Analgesics, Opioid, Animals, Brain, Chronic Pain, Drug Tolerance, Humans, Hyperalgesia, Neuroimaging, Opioid-Related Disorders, Pain Perception, Receptors, Opioid